Evaluation of immunoprophylactic efficacy of Brugia malayi transglutaminase (BmTGA) in single and multiple antigen vaccination with BmALT-2 and BmTPX for human lymphatic filariasis.
Identifieur interne : 006298 ( Main/Exploration ); précédent : 006297; suivant : 006299Evaluation of immunoprophylactic efficacy of Brugia malayi transglutaminase (BmTGA) in single and multiple antigen vaccination with BmALT-2 and BmTPX for human lymphatic filariasis.
Auteurs : Uma Vanam [Inde] ; Vivek Pandey ; Prince R. Prabhu ; Gajalakshmi Dakshinamurthy ; Maryada Venkata Rami Reddy ; Perumal KalirajSource :
- The American journal of tropical medicine and hygiene [ 1476-1645 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (génétique), Antigènes d'helminthe (immunologie), Brugia malayi (génétique), Brugia malayi (immunologie), Brugia malayi (pathogénicité), Filariose lymphatique (), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Gerbillinae, Humains, Mâle, Peroxirédoxines (génétique), Peroxirédoxines (immunologie), Protéines recombinantes (génétique), Protéines recombinantes (immunologie), Résultat thérapeutique, Transglutaminases (génétique), Transglutaminases (immunologie), Vaccins (administration et posologie), Vaccins (génétique), Vaccins (immunologie), Vaccins à ADN (administration et posologie), Vaccins à ADN (génétique), Vaccins à ADN (immunologie).
- MESH :
- administration et posologie : Vaccins, Vaccins à ADN.
- génétique : Antigènes d'helminthe, Brugia malayi, Peroxirédoxines, Protéines recombinantes, Transglutaminases, Vaccins, Vaccins à ADN.
- immunologie : Antigènes d'helminthe, Brugia malayi, Filariose lymphatique, Peroxirédoxines, Protéines recombinantes, Transglutaminases, Vaccins, Vaccins à ADN.
- parasitologie : Filariose lymphatique.
- pathogénicité : Brugia malayi.
- sang : Anticorps antihelminthe.
- Animaux, Filariose lymphatique, Gerbillinae, Humains, Mâle, Résultat thérapeutique.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antigens, Helminth (genetics), Antigens, Helminth (immunology), Brugia malayi (genetics), Brugia malayi (immunology), Brugia malayi (pathogenicity), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (prevention & control), Gerbillinae, Humans, Male, Peroxiredoxins (genetics), Peroxiredoxins (immunology), Recombinant Proteins (genetics), Recombinant Proteins (immunology), Transglutaminases (genetics), Transglutaminases (immunology), Treatment Outcome, Vaccines (administration & dosage), Vaccines (genetics), Vaccines (immunology), Vaccines, DNA (administration & dosage), Vaccines, DNA (genetics), Vaccines, DNA (immunology).
- MESH :
- chemical , administration & dosage : Vaccines, Vaccines, DNA.
- chemical , blood : Antibodies, Helminth.
- chemical , genetics : Antigens, Helminth, Peroxiredoxins, Recombinant Proteins, Transglutaminases, Vaccines, Vaccines, DNA.
- chemical , immunology : Antigens, Helminth, Peroxiredoxins, Recombinant Proteins, Transglutaminases, Vaccines, Vaccines, DNA.
- genetics : Brugia malayi.
- immunology : Brugia malayi, Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- pathogenicity : Brugia malayi.
- prevention & control : Elephantiasis, Filarial.
- Animals, Gerbillinae, Humans, Male, Treatment Outcome.
Abstract
An attempt was made to study the immunoprophylactic efficacy of recombinant Brugia malayi transglutaminase (BmTGA) as protein vaccine along with two other recombinant proteins, Brugia malayi abundant larval transcript-2 (BmALT-2) and Brugia malayi thioredoxin peroxidase (BmTPX), in single and multiple antigen form for human lymphatic filariasis. Parasite challenge studies in jirds exhibited protection of 30%, 69%, and 43% against BmTGA, BmALT-2, and BmTPX, respectively, in single antigen vaccination mode. The protective efficacy of BmTGA was enhanced significantly (74%) by immunizing the jirds in multiple antigen vaccination mode along with BmTPX, whereas immunizing with the combination of BmTGA and BmALT2 conferred only 47% protection. The same protection profiles were obtained by in vitro antibody-dependent cellular cytotoxicity, using live microfilariae and L3 stage larvae. The immune response was Th2 biased, irrespective of single or multiple vaccinations. The combination of BmTGA and BmTPX seems to be a promising vaccine candidate against lymphatic filariasis.
PubMed: 19190232
Affiliations:
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Le document en format XML
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<term>Antibodies, Helminth (blood)</term>
<term>Antigens, Helminth (genetics)</term>
<term>Antigens, Helminth (immunology)</term>
<term>Brugia malayi (genetics)</term>
<term>Brugia malayi (immunology)</term>
<term>Brugia malayi (pathogenicity)</term>
<term>Elephantiasis, Filarial (immunology)</term>
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<term>Elephantiasis, Filarial (prevention & control)</term>
<term>Gerbillinae</term>
<term>Humans</term>
<term>Male</term>
<term>Peroxiredoxins (genetics)</term>
<term>Peroxiredoxins (immunology)</term>
<term>Recombinant Proteins (genetics)</term>
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<term>Transglutaminases (genetics)</term>
<term>Transglutaminases (immunology)</term>
<term>Treatment Outcome</term>
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<term>Vaccines (genetics)</term>
<term>Vaccines (immunology)</term>
<term>Vaccines, DNA (administration & dosage)</term>
<term>Vaccines, DNA (genetics)</term>
<term>Vaccines, DNA (immunology)</term>
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<term>Antigènes d'helminthe (génétique)</term>
<term>Antigènes d'helminthe (immunologie)</term>
<term>Brugia malayi (génétique)</term>
<term>Brugia malayi (immunologie)</term>
<term>Brugia malayi (pathogénicité)</term>
<term>Filariose lymphatique ()</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Gerbillinae</term>
<term>Humains</term>
<term>Mâle</term>
<term>Peroxirédoxines (génétique)</term>
<term>Peroxirédoxines (immunologie)</term>
<term>Protéines recombinantes (génétique)</term>
<term>Protéines recombinantes (immunologie)</term>
<term>Résultat thérapeutique</term>
<term>Transglutaminases (génétique)</term>
<term>Transglutaminases (immunologie)</term>
<term>Vaccins (administration et posologie)</term>
<term>Vaccins (génétique)</term>
<term>Vaccins (immunologie)</term>
<term>Vaccins à ADN (administration et posologie)</term>
<term>Vaccins à ADN (génétique)</term>
<term>Vaccins à ADN (immunologie)</term>
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<term>Recombinant Proteins</term>
<term>Transglutaminases</term>
<term>Vaccines</term>
<term>Vaccines, DNA</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term>
<term>Peroxiredoxins</term>
<term>Recombinant Proteins</term>
<term>Transglutaminases</term>
<term>Vaccines</term>
<term>Vaccines, DNA</term>
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<term>Vaccins à ADN</term>
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<term>Brugia malayi</term>
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<term>Protéines recombinantes</term>
<term>Transglutaminases</term>
<term>Vaccins</term>
<term>Vaccins à ADN</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term>
<term>Brugia malayi</term>
<term>Filariose lymphatique</term>
<term>Peroxirédoxines</term>
<term>Protéines recombinantes</term>
<term>Transglutaminases</term>
<term>Vaccins</term>
<term>Vaccins à ADN</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">An attempt was made to study the immunoprophylactic efficacy of recombinant Brugia malayi transglutaminase (BmTGA) as protein vaccine along with two other recombinant proteins, Brugia malayi abundant larval transcript-2 (BmALT-2) and Brugia malayi thioredoxin peroxidase (BmTPX), in single and multiple antigen form for human lymphatic filariasis. Parasite challenge studies in jirds exhibited protection of 30%, 69%, and 43% against BmTGA, BmALT-2, and BmTPX, respectively, in single antigen vaccination mode. The protective efficacy of BmTGA was enhanced significantly (74%) by immunizing the jirds in multiple antigen vaccination mode along with BmTPX, whereas immunizing with the combination of BmTGA and BmALT2 conferred only 47% protection. The same protection profiles were obtained by in vitro antibody-dependent cellular cytotoxicity, using live microfilariae and L3 stage larvae. The immune response was Th2 biased, irrespective of single or multiple vaccinations. The combination of BmTGA and BmTPX seems to be a promising vaccine candidate against lymphatic filariasis.</div>
</front>
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<affiliations><list><country><li>Inde</li>
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<name sortKey="Pandey, Vivek" sort="Pandey, Vivek" uniqKey="Pandey V" first="Vivek" last="Pandey">Vivek Pandey</name>
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<name sortKey="Reddy, Maryada Venkata Rami" sort="Reddy, Maryada Venkata Rami" uniqKey="Reddy M" first="Maryada Venkata Rami" last="Reddy">Maryada Venkata Rami Reddy</name>
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<country name="Inde"><noRegion><name sortKey="Vanam, Uma" sort="Vanam, Uma" uniqKey="Vanam U" first="Uma" last="Vanam">Uma Vanam</name>
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